Detection of Tamoxifen Metabolites by GC-MSD
نویسندگان
چکیده
منابع مشابه
Detection of tamoxifen metabolites by GC-MSD.
Tamoxifen is an antiestrogen used in the adjuvant endocrine therapy of early breast cancer and malignant breast disorders. It is also used in women with anovulatory infertility caused by its stimulating effect on the secretion of the pituitary gonadotrophic hormones. In males it could increase the endogenous production of androgens. Because of these properties tamoxifen may be misused in some s...
متن کاملextremal region detection guided by maxima of gradient magnitude
a problem of computer vision applications is to detect regions of interest under dif- ferent imaging conditions. the state-of-the-art maximally stable extremal regions (mser) detects affine covariant regions by applying all possible thresholds on the input image, and through three main steps including: 1) making a component tree of extremal regions’ evolution (enumeration), 2) obtaining region ...
Chemometric Profiling of Whiskey Using the 5977A GC/MSD
Nontargeted compound analysis and statistical tools were used in combination with the high sensitivity of the Agilent 5977A Series GC/MSD with Extractor EI Source to generate compound profiles that were used to differentiate five brands of whiskey.
متن کاملThe Agilent 5977B GC/MSD and High Efficiency Source (HES) Lowers Detection for Semivolatile Compounds Authors
The enhanced signal produced by the High Efficiency Source (HES) of the Agilent 5977B GC/MSD allows for flexibility in analytical approach. To assist setting expectations for strategies in semivolatile organic compound analysis, this application note suggests preliminary instrument detection limits for a range of analytes of interest. The results show that picogram or sub-picogram detection in ...
متن کاملElimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation.
1-[4-(2-Dimethylaminoethoxy)-phenyl]-1,2-diphenylbut-1-(Z)-ene (tamoxifen, TAM) is a nonsteroidal antiestrogen that has been commonly used for the prevention and treatment of estrogen receptor-positive breast cancer. TAM is extensively metabolized into several primary active metabolites including 4-hydroxy-TAM (4-OH-TAM) and endoxifen. Glucuronidation is the major phase II metabolic pathway imp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2004
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/42.10.551